What is “PRP”?

PRP is the abbreviation of the initials of the words “Platelet Rich Plasma”. Platelets are important cells in blood coagulation and secrete many important growth factors such as IGF, TGF-B, VEGF. In PRP application, it is aimed to obtain these growth factors and use them in the target region.

What is mesotherapy?

The word “mesotherapy” is the combination of the words “meso” and “therapy”. It means the injection of hyaluronic acids, amino acids, coenzymes/cofactors, and vitamins with the help of small needles into the middle layer of the skin (“meso” derm) in the target area.


What are the areas of usage of PRP and mesotherapy?

PRP and mesotherapy are used to strengthen hair and prevent hair loss and used in skin rejuvenation, increasing the brightness of the skin, treatment of under-eye dark circles and stretch marks.


How do PRP and mesotherapy agents work?

When injected into the target area, PRP content provides growth factors, and mesotherapy agents provide hyaluronic acids, vitamins, minerals, coenzymes, cofactors, and amino acids. These agents increase cell repair, cell proliferation, collagen production, new blood vessel formation (angiogenesis) and dermal thickening. So, they delay aging.


What are the causes of hair loss?

Hair loss may be due to genetic/individual factors, metabolic/hormonal disorders, stress, medications, nutritional disorders and systemic disorders.


What are the mesotherapy products used in the treatment of hair loss, how does the combination of PRP and mesotherapy work?

Mesotherapy agents used in the treatment of hair loss contain different amounts of hyaluronic acids, vitamins (B5, B6, B7 (Biotin), Niacin, B12…) and amino acids (arginine, cysteine, glutamine…). These agents reduce hair loss, increase the thickness and the shine of existing hairs, strengthen hair follicles, repair damaged hairs, and increase vascular circulation of the hairs.


How are PRP and mesotherapy applied?

There is no need for operating room conditions for this procedure. It is one of the safe applications that can be done easily in office conditions where sterility principles are taken into account. First of all, PRP is prepared. With a special method, some blood of the patient is taken into special tubes. You can think of this process as a simple blood donation process for analysis. Then the blood taken into special tubes is subjected to centrifugation. In this process, the tube carrying your blood, which is placed in a special device, is rotated in rapid cycles and the blood is separated into different segments. The part rich in growth factors is taken and made ready for injection. Then the obtained PRP is mixed with the needed mesotherapy agents. This mixture is injected into the target layer in the target areas of the hair with fine-tipped needles. The preparation of PRP takes about 15 minutes, and the injection of PRP and mesotherapy takes about 10 minutes.


Are PRP and mesotherapy treatments stem cell treatments?

The answer is “no”. There are growth factors in PRP, and agents such as hyaluronic acid, vitamins and amino acids in mesotherapy agents. These are not stem cells. “Stem cells” are cells that have the potential to transform into many cells, such as repair cells, which are used in tissue regeneration due to their ability to renew themselves. Stem cells are found in the placenta, umbilical cord blood, bone marrow and adipose tissue. We prefer adipose tissue as a source of stem cells due to its ease of obtaining and abundance. They produce important proteins such as collagen/elastin, increase blood flow to the existing area, increase the nutrition of that area, thicken the dermis and reduce melanogenic activity. These stem cells obtained from adipose tissue are used in skin rejuvenation, in the treatment of hair loss, dark circles under the eyes, bad wound healing, bad healed scars, acne scars and in the treatment of hyperpigmentation (See Stem Cell (SVF) Therapy Section).


Which one is better, PRP/mesotherapy treatment or stem cell treatment? Can these treatments be combined?

Jeroen Stevens, M.D., Ph.D., whom I had the opportunity to work with in the Netherlands, devoted his years to these studies. He explains this issue as follows. When we look at the physiology of wound healing and the system that repairs wounds in our body, we see that 2 elements are very important. The first is signal pathways and growth factors to instruct repair cells. The others are “the repair cells” that do the actual work. We obtain the first element, the growth factors, from the PRP; and the second element, the repair cells, from the SVF, that is, from your own fat tissue. Studies have shown that it is much more effective to apply them to the target area in combination with the appropriate amount of mesotherapy agents, instead of applying them alone or separately. With these combinations, we support your skin to biologically repair itself.


Is PRP and mesotherapy application to the hair painful?

Since the injection needles used are quite small, the pain is minimal. If the part to be injected is large, there may be some pain. It is tried to provide superficial anesthesia before the procedure with topical creams. When deemed necessary, nerve blocks can be performed with local anesthetic injection and the pain is reduced. After the procedure, the feeling of pain and numbness at the injection sites will also disappear in a short time.


What should be considered after PRP and mesotherapy application?

Since the procedure is carried out in office conditions, it is possible to return to social life after the application. Burning sensation due to injections, numbness due to topical/local anesthesia are temporary. It is not recommended to wash the hair on the day of the procedure. At the day after the procedure, you can take a shower, return to your daily routine activities and routine hair care.


Are serious side effects expected after PRP and mesotherapy applications?

PRP is obtained from your own blood, and the mesotherapy agents used are substances with defined effects on wound healing in the body. Therefore, an allergic reaction or serious side effect is not expected.


When do PRP and mesotherapy applications for the treatment of hair loss start to show their effect, how many sessions should be done at what intervals?

Considering the life cycle of hair cells, the effect begins to be seen in about 1 month after the application. However, for increasing the effect and permanency, 4-6 sessions at 2-week intervals are recommended. It is thought that the application of a single session every 3-6 months after the treatment also increases the potency.


What are the factors affecting the results of PRP and mesotherapy applications?

The effect and duration of the applications vary according to the agents used, the combinations, the amount of damage to the hairs and hair follicles and individual factors. Age, metabolic/hormonal disorders, smoking, systemic disorders, genetic/structural causes, nutrition are some of these variable factors. Therefore, it is recommended that you do not compare this application with other applications and yourself with other people.


Combinations of PRP and mesotherapy are safe applications that are frequently used in the treatment of hair loss, and they can be easily performed in office conditions where sterility principles are taken into account. The pain can be tolerated with local anesthetics. When we examine the physiology of wound healing and the system that repairs wounds in our body, I think that PRP and mesotherapy combined with stem cell therapy are much more successful in the treatment of hair loss (See Stem Cell (SVF) Therapy Section). However, PRP/mesotherapy applications without stem cell treatment are also very effective in the treatment of hair loss for patients who do not want operating room conditions, who seek solutions in office conditions, and who comply with session intervals and numbers. Best regards.